Brian
Kraemer
PhD
(206) 762-1010
Seattle VA Puget Sound Health Care System
1660 S. Columbian Way
Box 358280 (S-182)
Seattle, WA 98108
Education & Training
- PhD, Biochemistry, University of Wisconsin, Madison WI (2000)
- College, Western Washington University, Bellingham WA (1994)
Honors
Faculty Senate (2020-2022)
Research Interests
As an investigator at the VA Puget Sound Health Care System, Dr. Kraemer’s research explores how protein aggregation contributes to neurodegenerative diseases including Alzheimer’s disease and amyotrophic lateral sclerosis. Dr. Kraemer has developed animal models of the tau pathology seen in Alzheimer’s disease using both transgenic mice and transgenic C. elegans. Dr. Kraemer’s current work focuses on dissecting the genetic requirements for tau mediated neurodegeneration in these models. The approach taken is to use the experimental advantages of C. elegans to identify genes involved tauopathy and TDP-43 proteinopathy. The role of these newly identified genes will be explored using transgenic mouse models. As new genes are identified that participate in tau and TDP-43 neurotoxicity, potential strategies for preventing neurodegeneration can be tested with the ultimate goal of developing effective therapies for neurodegenerative disease.
Publications
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